This is a list of the current House seats and the incumbents occupying them. All 435 of these seats are up for election on 2 November 2010.

There have been 0 deaths, 5 resignations, and 1 change of party affiliation in the 111^th House.

• Congressman Rahm Emanuel (Democratic, Illinois CD 5) resigned 2 January 2009 (vacancy effective 3 January) to become President-elect Barack Obama's Chief of Staff.
• Congressman Kirsten Gillibrand (Democratic, New York CD 20) resigned 26 January 2009. Governor David Paterson (Democratic, New York) appointed Congresswoman Kirsten Gillibrand to fill the vacancy in the State's Class 1 seat caused by the resignation of now-Secretary of State Hillary Rodham Clinton.
• Congressman Hilda L. Solis (Democratic, California CD 32) resigned 24 February to become Secretary of Labor. The vacancy became effective 25 February 2009.
• Congressman H. Scott Murphy (Democratic, New York CD 20) was elected to Congress on 31 March 2009 in Special Election. He fills the vacancy caused by the appointment of Congressman Kirsten Gillibrand to the United States Senate. Congressman Murphy took the oath of office on 29 April 2009.
• Congressman Mike Quigley (Democratic, Illinois CD 5) was elected in a special election on 7 April 2009. He fills the seat formerly held by Congressman Rahm Emanuel who resigned to become President Obama's Chief of Staff.
• Congressman Ellen O. Tauscher (Democratic California CD 10) resigned on 26 June 2009 to become Undersecretary of State for Arms Control and International Security.
• Congressman Judy Chu (Democratic California CD 32) was elected in a special election on 14 July 2009. She will fill the vacancy caused by the resignation of Congressman Hilda L. Solis to became Secretary of Labor.
• Congressman John McHugh (Republican New York CD 23) resigned 21 September 2009 to become Secretary of the Army.
• Congressman John Raymond Garamendi (Democratic California CD 10) was elected in a special election 3 November 2009. He will fill the vacancy caused by the resignation of Congressman Ellen O. Tauscher.
• Congressman William L. "Bill" Owens (Democratic New York CD 23) was elected in a special election 3 November 2009. He will fill the vacancy caused by the resignation of Congressman John McHugh.
• Congressman R. Parker "Parker" Griffith (Democratic, Alabama CD 5) changed his affiliation to the Republican Party on 22 December 2009.